Amlodipine – Long-acting calcium channel blocker for blood pressure control.
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What is Amlodipine?
Amlodipine is a widely prescribed calcium channel blocker that provides effective, long-lasting blood pressure control with once-daily dosing. It’s particularly valued for its consistent 24-hour blood pressure reduction and cardiovascular protection benefits.
Book an online consultation if you have concerns about high blood pressure, chest pain, or cardiovascular risk factors. Our GPs can assess your cardiovascular health and determine if Amlodipine or other blood pressure medications are appropriate for your specific needs.
What is Amlodipine used for?
- High blood pressure (hypertension)
- Angina (chest pain from heart disease)
- Coronary artery disease
- Prevention of cardiovascular events
- Raynaud's phenomenon (in some cases)
- Heart failure (as combination therapy)
How does Amlodipine work?
A calcium channel blocker that relaxes and widens blood vessels by blocking calcium channels in smooth muscle cells, reducing blood pressure and improving blood flow to the heart.
Dosage and Administration
Adults
Starting dose 5 mg once daily, may be increased to 10 mg once daily. Maximum 10 mg daily.
Children
Not routinely used in children—specialist supervision required if prescribed.
Important Notes
- Take at the same time each day for consistent blood pressure control.
- Can be taken with or without food.
- Do not stop suddenly—gradual dose reduction may be needed.
- Regular blood pressure monitoring required.
Side Effects
Common Side Effects
- Ankle swelling (peripheral edema)
- Flushing and feeling warm
- Headache
- Dizziness
- Fatigue
- Palpitations
- Nausea
Serious Side Effects
Seek immediate medical attention if you experience:
- Severe low blood pressure (hypotension)
- Severe allergic reactions
- Worsening heart failure
- Severe peripheral edema
- Liver problems (rare)
- Gum overgrowth (with long-term use)
Important Warnings
- May cause ankle swelling—report significant swelling to your GP.
- Can cause dizziness, especially when standing up—rise slowly from sitting or lying.
- Tell your GP if you have heart failure, liver disease, or severe aortic stenosis.
- Regular blood pressure checks needed to monitor effectiveness.
- May interact with grapefruit juice—avoid large amounts.
Drug Interactions
Tell your GP if you're taking any of the following medications:
- Grapefruit juice—may increase amlodipine levels and risk of side effects.
- Other blood pressure medications—additive blood pressure lowering effects.
- Simvastatin—amlodipine may increase simvastatin levels.
- Tacrolimus—may increase tacrolimus levels.
- CYP3A4 inhibitors—may increase amlodipine levels.
Frequently Asked Questions
Why do my ankles swell with Amlodipine?
Ankle swelling is a common side effect caused by blood vessel dilation and fluid retention. It affects about 10% of users and is usually mild, but report significant swelling to your GP.
How long does Amlodipine take to work?
You may notice blood pressure reduction within a few days, but full effects can take 6-8 weeks. It's designed for long-term daily use.
Can I stop taking Amlodipine if my blood pressure is normal?
No, don't stop without consulting your GP. The medication is likely what's keeping your blood pressure normal, and stopping suddenly could cause it to rise again.
Is it safe to take Amlodipine long-term?
Yes, it's designed for long-term use and is generally well-tolerated. Regular monitoring ensures it remains safe and effective for you.
Medically Reviewed by: Mohammed Hassan - Independent Prescriber
Last Updated: 2025-01-14