Atorvastatin – Powerful statin for cholesterol reduction and heart protection.
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What is Atorvastatin?
Atorvastatin is one of the most potent and widely prescribed statins for lowering cholesterol and preventing cardiovascular disease. Its proven ability to reduce heart attacks, strokes, and cardiovascular deaths makes it a cornerstone of modern preventive medicine.
Book an online consultation if you have high cholesterol, cardiovascular risk factors, or need assessment for statin therapy. Our GPs can evaluate your cardiovascular risk profile and determine if Atorvastatin or other cholesterol-lowering treatments are appropriate for your specific health needs.
What is Atorvastatin used for?
- High cholesterol (hypercholesterolaemia)
- Prevention of cardiovascular disease
- Secondary prevention after heart attack or stroke
- Familial hypercholesterolaemia
- Type 2 diabetes with cardiovascular risk
- Primary prevention in high-risk patients
- Mixed dyslipidaemia
How does Atorvastatin work?
A HMG-CoA reductase inhibitor (statin) that blocks cholesterol synthesis in the liver, reducing LDL ('bad') cholesterol and triglycerides while modestly increasing HDL ('good') cholesterol.
Dosage and Administration
Adults
Starting dose 10-20mg once daily in the evening. May be increased to 40-80mg daily based on cholesterol response.
Children
Familial hypercholesterolaemia: 10-20mg daily—specialist supervision required.
Important Notes
- Take once daily, preferably in the evening.
- Can be taken with or without food.
- Regular blood tests needed to monitor cholesterol and liver function.
- Continue taking even if you feel well—this is prevention medication.
Side Effects
Common Side Effects
- Muscle pain or weakness
- Headache
- Nausea and stomach upset
- Diarrhoea or constipation
- Joint pain
- Sleep disturbances
Serious Side Effects
Seek immediate medical attention if you experience:
- Severe muscle problems (rhabdomyolysis)
- Liver problems
- Diabetes (new onset or worsening)
- Severe allergic reactions
- Memory problems (rare)
- Cataracts (controversial)
Important Warnings
- Report any unexplained muscle pain, tenderness, or weakness immediately.
- Regular blood tests needed to monitor liver function and cholesterol levels.
- Tell your GP if you have liver disease, kidney problems, or thyroid disorders.
- May increase blood sugar—diabetes monitoring may be needed.
- Avoid excessive alcohol consumption while taking statins.
Drug Interactions
Tell your GP if you're taking any of the following medications:
- Grapefruit juice—avoid large amounts as it increases statin levels.
- Warfarin—may enhance anticoagulant effects.
- Ciclosporin—significantly increases atorvastatin levels.
- Clarithromycin and erythromycin—increase risk of muscle problems.
- Amlodipine—may increase atorvastatin levels.
- Digoxin—may increase digoxin levels.
Frequently Asked Questions
How long does it take for Atorvastatin to lower cholesterol?
Cholesterol levels typically start dropping within 2 weeks, with maximum effects usually seen after 4-6 weeks of treatment.
Do I need to follow a special diet while taking Atorvastatin?
A heart-healthy diet enhances the benefits, but Atorvastatin works even without dietary changes. Avoid grapefruit juice in large amounts.
Can I stop taking Atorvastatin if my cholesterol normalizes?
No, don't stop without consulting your GP. Cholesterol will likely rise again within weeks of stopping, and the cardiovascular protection will be lost.
Why do I need regular blood tests?
To monitor cholesterol response, check liver function (rare liver problems), and assess for diabetes development, ensuring the medication remains safe and effective.
Medically Reviewed by: Mohammed Hassan - Independent Prescriber
Last Updated: 2025-01-14