Cyclizine – Effective antihistamine for motion sickness and nausea.
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What is Cyclizine?
Cyclizine is a well-tolerated antihistamine medication that’s particularly effective for preventing and treating motion sickness, nausea, and vomiting from various causes. It’s often preferred for travel sickness due to its balance of effectiveness and relatively mild sedating effects.
Book an online consultation if you’re experiencing motion sickness, persistent nausea, or balance problems that may benefit from antihistamine treatment. Our GPs can assess your symptoms and determine if Cyclizine is the right medication for your specific needs.
What is Cyclizine used for?
- Motion sickness and travel nausea
- Nausea and vomiting from various causes
- Vertigo and balance disorders
- Post-operative nausea and vomiting
- Morning sickness in pregnancy (under medical supervision)
- Nausea from medications or chemotherapy
- Inner ear problems causing dizziness
How does Cyclizine work?
An antihistamine that blocks histamine and acetylcholine receptors in the brain's vomiting center, reducing nausea, vomiting, and motion-related symptoms.
Dosage and Administration
Adults
50 mg taken up to 3 times daily. For motion sickness: take 30 minutes before travel.
Children
Children 6-12 years: 25 mg up to 3 times daily. Under 6 years: specialist advice needed.
Important Notes
- For motion sickness: take 30 minutes before traveling.
- Can be taken with or without food.
- May cause drowsiness—avoid driving initially.
- Maximum 150 mg daily for adults.
Side Effects
Common Side Effects
- Drowsiness and sedation
- Dry mouth
- Blurred vision
- Constipation
- Difficulty urinating
- Dizziness
- Headache
Serious Side Effects
Seek immediate medical attention if you experience:
- Severe allergic reactions
- Heart rhythm changes (rare)
- Confusion (especially in elderly)
- Severe constipation or bowel obstruction
- Inability to urinate
- Seizures (rare)
Important Warnings
- May cause drowsiness—avoid driving or operating machinery until you know how it affects you.
- Use with caution in elderly patients—increased risk of confusion and falls.
- Tell your GP if you have glaucoma, enlarged prostate, or heart problems.
- Not recommended for children under 6 years without specialist advice.
- Avoid alcohol as it increases drowsiness.
Drug Interactions
Tell your GP if you're taking any of the following medications:
- Alcohol—increases drowsiness and impairs coordination.
- Other sedating medications—additive drowsiness effects.
- Anticholinergic drugs—increased risk of dry mouth, constipation, confusion.
- MAOIs—may enhance anticholinergic effects.
- Tricyclic antidepressants—increased anticholinergic side effects.
Frequently Asked Questions
How long before travel should I take Cyclizine?
Take Cyclizine 30 minutes before traveling for best prevention of motion sickness. It can also be taken after symptoms start, but prevention is more effective.
Can I take Cyclizine for morning sickness?
Cyclizine can be used for pregnancy-related nausea, but only under medical supervision. Your GP will weigh the benefits and risks for your specific situation.
How long does the drowsiness last?
Drowsiness typically peaks 1-2 hours after taking Cyclizine and can last 4-6 hours. This effect may reduce with regular use as your body adjusts.
Is Cyclizine better than other travel sickness medications?
Cyclizine is effective for most people and causes less drowsiness than some alternatives like Promethazine, making it popular for daytime use.
Medically Reviewed by: Mohammed Hassan - Independent Prescriber
Last Updated: 2025-01-14