Diclofenac – Powerful NSAID for pain and inflammation relief.
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What is Diclofenac?
Diclofenac is a potent NSAID that’s highly effective for treating pain and inflammation from various musculoskeletal conditions. Available in both oral and topical forms, it provides flexible treatment options while requiring careful attention to cardiovascular and gastrointestinal risks.
Book an online consultation if you’re experiencing joint pain, muscle inflammation, or injury-related pain that may benefit from anti-inflammatory treatment. Our GPs can assess your symptoms and determine if Diclofenac is appropriate while considering your individual risk factors.
What is Diclofenac used for?
- Rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
- Acute musculoskeletal injuries
- Back pain and sciatica
- Sports injuries
- Post-operative pain
- Migraine (specific formulations)
- Topical use for localized pain
How does Diclofenac work?
A non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin production and thereby decreasing pain, inflammation, and fever.
Dosage and Administration
Adults
Oral: 75-150 mg daily in divided doses. Topical gel: apply 2-4 times daily. Maximum 150 mg daily oral.
Children
Not recommended for children under 14 years for oral use. Topical use may be considered under medical supervision.
Important Notes
- Take oral tablets with or after food to reduce stomach irritation.
- Apply topical gel thinly to affected area and rub in gently.
- Use the lowest effective dose for the shortest time possible.
- Do not exceed recommended dose or duration.
Side Effects
Common Side Effects
- Stomach upset and nausea
- Indigestion and heartburn
- Diarrhoea
- Headache
- Dizziness
- Skin irritation (with topical use)
Serious Side Effects
Seek immediate medical attention if you experience:
- Stomach ulcers and bleeding
- Heart attack and stroke (increased risk)
- Kidney problems
- Liver damage
- Severe allergic reactions
- High blood pressure
- Fluid retention and swelling
Important Warnings
- Increased risk of heart attack and stroke—use lowest dose for shortest time.
- Tell your GP if you have heart disease, high blood pressure, or kidney problems.
- Not suitable if you have stomach ulcers, severe heart failure, or kidney disease.
- Avoid if you're allergic to aspirin or other NSAIDs.
- Regular monitoring may be needed for long-term use.
Drug Interactions
Tell your GP if you're taking any of the following medications:
- Warfarin—significantly increases bleeding risk.
- ACE inhibitors—may reduce kidney function and blood pressure control.
- Diuretics—may reduce effectiveness and increase kidney problems.
- Lithium—may increase lithium levels and toxicity.
- Methotrexate—increases risk of methotrexate toxicity.
- Other NSAIDs—avoid combination due to increased side effect risk.
Frequently Asked Questions
Is topical Diclofenac safer than tablets?
Yes, topical Diclofenac has much lower systemic absorption and fewer side effects, making it safer for localized pain and inflammation.
Can I take Diclofenac with paracetamol?
Yes, paracetamol can be safely combined with Diclofenac and may provide better pain relief than either medication alone.
Why do I need to be careful about heart risks?
All NSAIDs, including Diclofenac, can increase the risk of heart attack and stroke, especially with long-term use or in people with existing heart disease.
How long can I safely use Diclofenac?
For acute pain, use for the shortest time possible (usually 3-7 days). For chronic conditions, your GP will monitor you regularly and reassess the need periodically.
Medically Reviewed by: Mohammed Hassan - Independent Prescriber
Last Updated: 2025-01-14