Dymista – Dual-action nasal spray combining steroid and antihistamine.
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What is Dymista?
Dymista provides superior allergic rhinitis control by combining the immediate relief of an antihistamine with the long-term anti-inflammatory benefits of a nasal steroid. This dual-action approach makes it particularly effective for moderate to severe hay fever that doesn’t respond adequately to single-ingredient treatments.
Book an online consultation if you’re experiencing persistent hay fever or allergic rhinitis symptoms, need better control of seasonal allergies, or have nasal allergy symptoms that interfere with sleep or daily activities. Our GPs can assess your allergy symptoms and determine if Dymista or other allergy treatments are appropriate for your specific condition.
What is Dymista used for?
- Allergic rhinitis (hay fever)
- Seasonal allergic rhinitis
- Perennial allergic rhinitis
- Severe nasal allergy symptoms
- Allergic rhinitis not responding to single treatments
- Moderate to severe hay fever
- Year-round nasal allergies
How does Dymista work?
Combines fluticasone propionate (a corticosteroid that reduces inflammation and prevents allergic reactions) with azelastine (an antihistamine that blocks histamine receptors), providing both immediate and long-term relief from allergic nasal symptoms.
Dosage and Administration
Adults
One spray in each nostril twice daily (morning and evening). Each spray contains 50mcg fluticasone and 137mcg azelastine.
Children
Children 6-11 years: One spray in each nostril twice daily. Not recommended under 6 years.
Important Notes
- Shake bottle gently before each use.
- Prime the spray before first use or if not used for 7+ days.
- Avoid spraying directly onto nasal septum.
- Use regularly for best effect, even when not symptomatic.
Side Effects
Common Side Effects
- Bitter taste
- Headache
- Nosebleeds (epistaxis)
- Nasal irritation or burning
- Drowsiness
- Sneezing after application
- Dry mouth
Serious Side Effects
Seek immediate medical attention if you experience:
- Severe nosebleeds
- Signs of nasal infection
- Vision problems
- Severe allergic reactions
- Nasal septum perforation (very rare)
- Systemic steroid effects (rare)
Important Warnings
- Tell your GP if you have recent nasal surgery, injury, or ulcers.
- Avoid contact with eyes—rinse thoroughly if contact occurs.
- May cause drowsiness—avoid driving until you know how it affects you.
- Report persistent nosebleeds or nasal pain to your GP.
- Long-term use may affect growth in children—regular monitoring needed.
Drug Interactions
Tell your GP if you're taking any of the following medications:
- Alcohol and sedating medications—may increase drowsiness.
- CYP3A4 inhibitors (ketoconazole, ritonavir)—may increase fluticasone levels.
- Other nasal steroids—avoid concurrent use.
- CNS depressants—may enhance sedative effects.
Frequently Asked Questions
Why does Dymista combine a steroid with an antihistamine?
The combination provides both immediate relief (from azelastine) and long-term prevention (from fluticasone), making it more effective than either ingredient alone for moderate to severe allergic rhinitis.
How is Dymista different from using separate nasal sprays?
The combination ensures both medications reach the same nasal tissues simultaneously and in optimal ratios, often providing superior symptom control than separate sprays.
Why do I get a bitter taste with Dymista?
The bitter taste is mainly from azelastine and is very common. Proper spraying technique (aiming away from the septum) can help minimize this.
How long before I see full benefits from Dymista?
Some relief may be immediate from the antihistamine component, but full anti-inflammatory benefits from the steroid may take several days to weeks of regular use.
Medically Reviewed by: Mohammed Hassan - Independent Prescriber
Last Updated: 2025-01-14