Mebeverine – Smooth muscle antispasmodic for IBS and bowel disorders.
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What is Mebeverine?
Mebeverine is a highly effective and well-tolerated antispasmodic medication that’s specifically designed for treating IBS and functional bowel disorders. Its excellent safety profile and lack of anticholinergic side effects make it a preferred choice for long-term bowel symptom management.
Book an online consultation if you’re experiencing IBS symptoms, chronic abdominal cramps, or bowel spasms that are affecting your quality of life. Our GPs can assess your digestive symptoms and determine if Mebeverine or other IBS treatments are appropriate for your specific condition.
What is Mebeverine used for?
- Irritable bowel syndrome (IBS)
- Functional bowel disorders
- Abdominal cramps and spasms
- Chronic abdominal pain
- Post-infectious IBS
- Diverticular disease symptoms
- Functional dyspepsia
How does Mebeverine work?
A direct-acting smooth muscle antispasmodic that works specifically on the smooth muscle of the gastrointestinal tract, reducing muscle spasms and cramping without affecting normal gut motility.
Dosage and Administration
Adults
135mg three times daily, taken 20 minutes before meals. Modified-release: 200mg twice daily.
Children
Children over 10 years: adult dose. Under 10 years: specialist advice required.
Important Notes
- Take 20 minutes before meals for best effect.
- Can be taken with water but avoid taking with food.
- Modified-release tablets should be swallowed whole.
- May take several weeks to see full benefit.
Side Effects
Common Side Effects
- Generally very well tolerated
- Mild skin rash (rare)
- Dizziness (rare)
- Headache (rare)
Serious Side Effects
Seek immediate medical attention if you experience:
- Severe allergic reactions (very rare)
- Angioedema (swelling of face, lips, tongue)
Important Warnings
- Generally one of the safest antispasmodics available.
- Tell your GP if you develop skin rash or swelling.
- Not suitable for patients with paralytic ileus.
- Stop if you develop severe allergic reactions.
- Safe for long-term use in most patients.
Drug Interactions
Tell your GP if you're taking any of the following medications:
- Generally no significant drug interactions.
- Does not affect other medications' absorption.
- Safe to use with most other medications.
- No interactions with food apart from timing of administration.
Frequently Asked Questions
How is Mebeverine different from Buscopan?
Mebeverine works directly on smooth muscle and doesn't have the anticholinergic side effects (dry mouth, constipation, blurred vision) that Buscopan can cause.
Why do I need to take it before meals?
Taking it before meals allows the medication to be in your system when food triggers gut muscle activity, providing better prevention of spasms.
How long does it take to work for IBS?
Some people notice improvement within days, but it may take 2-4 weeks of regular use to see the full benefit for IBS symptoms.
Can I take Mebeverine long-term?
Yes, it's safe for long-term use and is often taken continuously by people with chronic IBS to prevent symptoms.
Medically Reviewed by: Mohammed Hassan - Independent Prescriber
Last Updated: 2025-01-14