Miconazole – Broad-spectrum imidazole antifungal for skin and oral infections.
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What is Miconazole?
Miconazole (Daktarin) is a versatile broad-spectrum antifungal medication available in multiple formulations for treating fungal infections at various body sites. Its effectiveness against a wide range of fungi makes it a popular choice for both oral and topical fungal infections.
Book an online consultation if you’re experiencing persistent fungal infections, oral thrush, skin fungal conditions, or need assessment for antifungal treatment options. Our GPs can evaluate your symptoms and determine if Miconazole or other antifungal treatments are appropriate for your specific fungal condition.
What is Miconazole used for?
- Oral thrush (oral candidiasis)
- Skin fungal infections (athlete's foot, ringworm)
- Vaginal thrush
- Nail fungal infections
- Fungal skin conditions (tinea)
- Denture-related oral thrush
- Intertrigo (skin fold infections)
- Seborrheic dermatitis
How does Miconazole work?
An imidazole antifungal that inhibits ergosterol synthesis in fungal cell membranes, disrupting cell membrane integrity and causing fungal cell death.
Dosage and Administration
Adults
Oral gel: 2.5ml four times daily. Cream: apply twice daily. Pessaries: 100mg daily for 7 days or 1.2g single dose.
Children
Oral gel: 1.25ml four times daily for children 4 months-2 years. Topical same as adults.
Important Notes
- For oral thrush: hold gel in mouth before swallowing.
- Apply creams to clean, dry skin and surrounding area.
- Continue treatment for 1 week after symptoms clear.
- Wash hands before and after application.
Side Effects
Common Side Effects
- Nausea (with oral gel)
- Local irritation or burning
- Skin rash at application site
- Bad taste (oral preparations)
- Stomach upset
Serious Side Effects
Seek immediate medical attention if you experience:
- Severe allergic reactions
- Liver problems (rare with topical use)
- Severe local reactions
- Contact dermatitis
Important Warnings
- Tell your GP if you have liver problems when using oral preparations.
- Not suitable for babies under 4 months for oral gel.
- May interact with warfarin—monitor bleeding if using oral gel.
- Avoid contact with eyes and mucous membranes (topical preparations).
- Stop if severe irritation or allergic reaction develops.
Drug Interactions
Tell your GP if you're taking any of the following medications:
- Warfarin—oral miconazole may increase bleeding risk significantly.
- Phenytoin—may increase phenytoin levels.
- Sulfonylureas (diabetes medications)—may increase hypoglycemia risk.
- Ciclosporin—may increase ciclosporin levels.
- Generally minimal interactions with topical use.
Frequently Asked Questions
How is Miconazole different from Nystatin for oral thrush?
Miconazole has broader antifungal activity and may be more effective against resistant Candida strains, but Nystatin is safer in very young babies.
Can I use Miconazole cream for vaginal thrush?
Yes, but vaginal pessaries or creams specifically designed for vaginal use are usually preferred as they're formulated for the vaginal environment.
How long does it take to work for skin infections?
Improvement usually begins within 2-4 days, but continue treatment for at least 1 week after symptoms disappear to prevent recurrence.
Why does oral Miconazole interact with Warfarin?
Oral miconazole is absorbed and can inhibit warfarin metabolism, significantly increasing bleeding risk. This doesn't occur with topical use.
Medically Reviewed by: Mohammed Hassan - Independent Prescriber
Last Updated: 2025-01-14