Naproxen – Long-acting NSAID for pain and inflammation relief.
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What is Naproxen?
Naproxen is a long-acting non-steroidal anti-inflammatory drug (NSAID) used to treat pain, inflammation, and fever. It’s particularly effective for musculoskeletal pain, arthritis, and menstrual pain, providing relief for up to 12 hours per dose.
Book an online consultation if you’re experiencing persistent pain or inflammation that may benefit from anti-inflammatory treatment. Our GPs can assess your condition and determine if Naproxen is safe and appropriate for you.
What is Naproxen used for?
- Arthritis and joint pain
- Back pain and sciatica
- Menstrual pain (dysmenorrhoea)
- Muscle strains and sprains
- Dental pain
- Gout attacks
- Post-operative pain
- Headaches and migraines
How does Naproxen work?
A non-steroidal anti-inflammatory drug (NSAID) that reduces inflammation, pain, and fever by blocking cyclooxygenase enzymes that produce prostaglandins.
Dosage and Administration
Adults
250-500 mg twice daily with food. Maximum 1000 mg daily.
Children
Not recommended for children under 16 years unless specifically prescribed by a specialist.
Important Notes
- Always take with or after food to protect your stomach.
- Use the lowest effective dose for the shortest time needed.
- Allow 12 hours between doses.
- Do not exceed the maximum daily dose.
Side Effects
Common Side Effects
- Stomach upset and indigestion
- Nausea and vomiting
- Diarrhoea or constipation
- Dizziness
- Headache
- Skin rash
Serious Side Effects
Seek immediate medical attention if you experience:
- Stomach ulcers and bleeding
- Heart attack and stroke (with long-term use)
- Kidney problems
- Severe allergic reactions
- Liver problems
- High blood pressure
Important Warnings
- Not suitable if you have a history of stomach ulcers or bleeding.
- Increases risk of heart attack and stroke—use lowest dose for shortest time.
- Tell your GP if you have heart disease, high blood pressure, or kidney problems.
- Avoid if you're allergic to aspirin or other NSAIDs.
- Not recommended in the third trimester of pregnancy.
Drug Interactions
Tell your GP if you're taking any of the following medications:
- Warfarin and blood thinners—significantly increases bleeding risk.
- ACE inhibitors and diuretics—may reduce effectiveness and increase kidney risk.
- Lithium—may increase lithium levels.
- Methotrexate—increases risk of methotrexate toxicity.
- Aspirin—increases risk of stomach bleeding.
- Steroids—further increases stomach bleeding risk.
Frequently Asked Questions
Why must I take Naproxen with food?
Food helps protect your stomach lining from irritation. Taking NSAIDs on an empty stomach significantly increases the risk of stomach ulcers and bleeding.
How is Naproxen different from ibuprofen?
Naproxen lasts longer (12 hours vs 6-8 hours for ibuprofen) so you need fewer doses, but it may have slightly higher risks of stomach and heart side effects.
Can I take Naproxen for a hangover headache?
It's not recommended. Alcohol already irritates your stomach, and NSAIDs can make this worse. Paracetamol is safer for hangover headaches.
How long can I safely take Naproxen?
For acute pain, usually 5-7 days. For chronic conditions like arthritis, longer use requires regular GP monitoring for side effects.
Medically Reviewed by: Mohammed Hassan - Independent Prescriber
Last Updated: 2025-01-14