Nystatin – Topical polyene antifungal for Candida infections.
Get expert medical advice and same-day prescriptions from qualified UK doctors through our secure online consultation platform.
- Professional online consultation and prescription
- Same-day service when clinically appropriate
- Secure delivery to your chosen pharmacy
Secure Telehealth Platform Trusted by Over 150,000 Patients
What is Nystatin?
Nystatin is a safe and effective topical antifungal medication that’s particularly valuable for Candida infections in various body sites. Its lack of systemic absorption makes it suitable for long-term use and safe for use in pregnancy and children.
Book an online consultation if you’re experiencing symptoms of thrush, persistent fungal skin infections, or recurrent Candida infections. Our GPs can assess your symptoms and determine if Nystatin or other antifungal treatments are appropriate for your specific fungal condition.
What is Nystatin used for?
- Oral thrush (oral candidiasis)
- Vaginal thrush (vaginal candidiasis)
- Skin candida infections
- Nappy rash with fungal infection
- Intestinal candidiasis
- Prevention of fungal infections in immunocompromised patients
- Denture-related oral thrush
How does Nystatin work?
A polyene antifungal that binds to ergosterol in fungal cell membranes, creating pores that cause cell death. It's not absorbed systemically, providing targeted local antifungal action.
Dosage and Administration
Adults
Oral suspension: 1ml four times daily. Pessaries: 100,000-200,000 units daily. Cream/ointment: apply 2-4 times daily.
Children
Oral suspension: 1ml four times daily for babies and children. Topical preparations same as adults.
Important Notes
- For oral thrush: hold suspension in mouth before swallowing.
- Continue treatment for 48 hours after symptoms clear.
- Apply creams to clean, dry skin.
- For vaginal thrush: insert pessaries high into vagina at bedtime.
Side Effects
Common Side Effects
- Nausea (with oral suspension)
- Local irritation or burning
- Skin rash at application site
- Bad taste (oral suspension)
- Vaginal irritation (with pessaries)
Serious Side Effects
Seek immediate medical attention if you experience:
- Severe allergic reactions (rare)
- Severe local irritation
- Worsening of infection (if not fungal)
- Contact dermatitis
Important Warnings
- Not effective against bacterial infections—only use for confirmed fungal infections.
- Tell your GP if symptoms worsen or don't improve within 7 days.
- For vaginal use: avoid during pregnancy unless specifically prescribed.
- May stain clothing—use appropriate protection.
- Not absorbed systemically so safe for long-term use if needed.
Drug Interactions
Tell your GP if you're taking any of the following medications:
- Generally no significant drug interactions due to minimal absorption.
- Safe to use with most other medications.
- Does not interact with oral contraceptives.
- Compatible with most topical preparations.
Frequently Asked Questions
How long does Nystatin take to work for oral thrush?
Improvement usually begins within 2-3 days, but continue treatment for 48 hours after symptoms disappear to prevent recurrence.
Why doesn't Nystatin work for all types of thrush?
Nystatin specifically targets Candida species. Some resistant Candida strains or other fungal infections may require different antifungals like fluconazole.
Can I use Nystatin if I'm pregnant or breastfeeding?
Oral and topical Nystatin are generally safe in pregnancy and breastfeeding as they're not absorbed systemically, but always consult your GP first.
Why do I need to continue treatment after symptoms disappear?
Continuing for 48 hours after visible symptoms clear ensures all fungal organisms are eliminated and reduces the risk of recurrence.
Medically Reviewed by: Mohammed Hassan - Independent Prescriber
Last Updated: 2025-01-14