Phenoxymethylpenicillin – Oral penicillin antibiotic for bacterial infections.
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What is Phenoxymethylpenicillin?
Phenoxymethylpenicillin (also known as Penicillin V) is an oral penicillin antibiotic used to treat various bacterial infections. It’s particularly effective for throat infections, skin infections, and dental problems.
Book an online consultation if you’re experiencing symptoms that may require antibiotic treatment. Our GPs can assess your condition and prescribe appropriate medication if clinically indicated.
What is Phenoxymethylpenicillin used for?
- Throat infections (e.g., strep throat, tonsillitis)
- Skin and soft tissue infections
- Dental infections
- Prophylaxis against rheumatic fever
- Mild respiratory tract infections
How does Phenoxymethylpenicillin work?
A penicillin antibiotic that works by interfering with bacterial cell wall synthesis, causing bacteria to break down and die.
Dosage and Administration
Adults
250-500 mg every 6 hours, taken on an empty stomach.
Children
Dose calculated based on weight—your GP will advise the appropriate amount.
Important Notes
- Take on an empty stomach (1 hour before or 2 hours after meals).
- Complete the full course even if symptoms improve.
- Take at evenly spaced intervals throughout the day.
Side Effects
Common Side Effects
- Nausea and vomiting
- Diarrhoea
- Abdominal pain
- Skin rash
Serious Side Effects
Seek immediate medical attention if you experience:
- Severe allergic reactions (anaphylaxis)
- Severe diarrhoea with blood or mucus
- Difficulty breathing or swallowing
- Severe skin reactions
Important Warnings
- Do not take if you have a known penicillin or beta-lactam allergy.
- Inform your GP if you have a history of allergic reactions to antibiotics.
- May reduce effectiveness of oral contraceptives—use additional contraception.
- Tell your GP if you have kidney problems or glandular fever.
Drug Interactions
Tell your GP if you're taking any of the following medications:
- Methotrexate – increased risk of toxicity.
- Oral contraceptives – reduced effectiveness.
- Warfarin and other anticoagulants – may enhance anticoagulant effect.
- Probenecid – may increase penicillin levels.
Frequently Asked Questions
Why must I take Phenoxymethylpenicillin on an empty stomach?
Food can reduce the absorption of this antibiotic, making it less effective. Take it 1 hour before or 2 hours after meals for best results.
Can I get Phenoxymethylpenicillin without a prescription?
No. All antibiotics require a prescription from a UK-registered healthcare professional after proper assessment.
What's the difference between this and Amoxicillin?
Phenoxymethylpenicillin must be taken on an empty stomach and is typically used for throat and skin infections, while Amoxicillin can be taken with food and has broader uses.
Medically Reviewed by: Mohammed Hassan - Independent Prescriber
Last Updated: 2025-01-14