Prednisolone – Corticosteroid for inflammation and allergic reactions.
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What is Prednisolone?
Prednisolone is a synthetic corticosteroid used to treat a wide range of inflammatory and autoimmune conditions. It’s a powerful anti-inflammatory medication that can provide rapid relief from severe symptoms but requires careful monitoring due to potential side effects.
Book an online consultation if you’re experiencing severe allergic reactions, asthma exacerbations, or inflammatory conditions that may require corticosteroid treatment. Our GPs can assess your condition and determine if Prednisolone is appropriate for you.
What is Prednisolone used for?
- Asthma exacerbations
- Allergic reactions
- Inflammatory bowel disease flares
- Rheumatoid arthritis
- Eczema and severe skin conditions
- Temporal arteritis
- Polymyalgia rheumatica
- COPD exacerbations
How does Prednisolone work?
A synthetic corticosteroid that mimics cortisol, reducing inflammation and suppressing the immune system's response to various triggers.
Dosage and Administration
Adults
5-80 mg daily depending on condition—usually started at higher dose then gradually reduced.
Children
1-2 mg per kg daily—specialist supervision usually required.
Important Notes
- Take with food to reduce stomach upset.
- Usually taken as a single morning dose.
- Do not stop suddenly—dose must be gradually reduced.
- Take at the same time each day, preferably in the morning.
Side Effects
Common Side Effects
- Increased appetite and weight gain
- Mood changes (irritability, euphoria)
- Difficulty sleeping
- Increased blood sugar levels
- Fluid retention and swelling
- Increased susceptibility to infections
Serious Side Effects
Seek immediate medical attention if you experience:
- Osteoporosis (with long-term use)
- Diabetes mellitus
- High blood pressure
- Stomach ulcers
- Severe mood changes or psychosis
- Adrenal suppression
- Growth suppression in children
Important Warnings
- Never stop taking suddenly—risk of adrenal crisis.
- May mask signs of infection—tell your GP if you feel unwell.
- Avoid live vaccines while taking prednisolone.
- Long-term use requires regular monitoring of blood pressure, blood sugar, and bone density.
- May worsen diabetes—close blood sugar monitoring required.
Drug Interactions
Tell your GP if you're taking any of the following medications:
- NSAIDs (ibuprofen, aspirin)—increased risk of stomach ulcers.
- Warfarin—may enhance or reduce anticoagulant effects.
- Diabetic medications—may require dose adjustments.
- Live vaccines—avoid while taking prednisolone.
- Phenytoin, carbamazepine—may reduce prednisolone effectiveness.
Frequently Asked Questions
Why can't I stop Prednisolone suddenly?
Stopping suddenly can cause adrenal crisis, a life-threatening condition. Your body needs time to restart its own cortisol production, so the dose must be gradually reduced.
Will I gain weight on Prednisolone?
Weight gain is common due to increased appetite and fluid retention. Try to maintain a healthy diet and regular exercise while taking it.
How long can I take Prednisolone safely?
Short courses (up to 3 weeks) are generally safe. Longer use requires careful monitoring for side effects and may need additional medications to protect bones and stomach.
Why do I feel so energetic and unable to sleep?
Prednisolone can cause euphoria and insomnia. Taking it in the morning and avoiding caffeine in the evening may help with sleep.
Medically Reviewed by: Mohammed Hassan - Independent Prescriber
Last Updated: 2025-01-14