Tranexamic Acid – Antifibrinolytic agent for heavy bleeding and clotting support.
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What is Tranexamic Acid?
Tranexamic acid is a highly effective antifibrinolytic medication that’s particularly valuable for managing heavy menstrual bleeding and preventing excessive bleeding in various medical situations. Its ability to stabilize blood clots makes it an essential tool for bleeding disorders.
Book an online consultation if you’re experiencing heavy menstrual bleeding, need bleeding management for dental procedures, or have concerns about excessive bleeding. Our GPs can assess your bleeding patterns and determine if Tranexamic acid is appropriate while evaluating your clotting risk factors.
What is Tranexamic Acid used for?
- Heavy menstrual bleeding (menorrhagia)
- Bleeding after tooth extraction or surgery
- Hereditary angioedema
- Post-partum haemorrhage prevention
- Trauma-related bleeding
- Bleeding in patients on anticoagulants
- Epistaxis (nosebleeds)
- Local fibrinolysis conditions
How does Tranexamic Acid work?
An antifibrinolytic agent that inhibits plasminogen activation and plasmin activity, preventing the breakdown of fibrin clots and reducing bleeding by stabilizing blood clots once formed.
Dosage and Administration
Adults
Heavy periods: 1g three times daily during menstruation. Dental procedures: 1g 2-3 times daily for 2-8 days. IV doses for severe bleeding.
Children
20-25mg per kg three times daily—specialist supervision usually required.
Important Notes
- Take with or without food.
- For menstrual bleeding: start when heavy bleeding begins, stop when bleeding becomes normal.
- For procedures: start before treatment and continue as advised.
- Swallow tablets whole with water.
Side Effects
Common Side Effects
- Nausea and vomiting
- Diarrhoea
- Stomach upset
- Dizziness
- Headache
- Fatigue
Serious Side Effects
Seek immediate medical attention if you experience:
- Blood clots (thromboembolism)
- Stroke or heart attack
- Pulmonary embolism
- Deep vein thrombosis
- Severe allergic reactions
- Kidney problems
- Visual disturbances
Important Warnings
- Tell your GP if you have a history of blood clots, heart disease, or stroke.
- Not suitable for patients with active blood clots or high clotting risk.
- May increase risk of seizures in some patients.
- Tell your GP if you have kidney problems—dose adjustment needed.
- Stop immediately if you develop chest pain, leg swelling, or sudden breathlessness.
Drug Interactions
Tell your GP if you're taking any of the following medications:
- Hormonal contraceptives—may increase clotting risk when used together.
- HRT—increased risk of blood clots.
- Factor IX complex concentrates—increased thrombosis risk.
- Tissue plasminogen activator—antagonistic effects.
- Generally safe with most other medications.
Frequently Asked Questions
How effective is Tranexamic acid for heavy periods?
Studies show it can reduce menstrual blood loss by up to 40-50%, making it one of the most effective non-hormonal treatments for heavy menstrual bleeding.
How quickly does it work for bleeding?
It starts working within hours of taking it, but maximum effect for menstrual bleeding may take 2-3 cycles of regular use during periods.
Is it safe to use every month for heavy periods?
Yes, it's safe to use during each menstrual cycle, but only take it during the days of heavy bleeding, not continuously throughout the month.
Can I take Tranexamic acid if I'm on the contraceptive pill?
Generally yes, but there may be a slightly increased risk of blood clots. Your GP will assess your individual risk factors before prescribing.
Medically Reviewed by: Mohammed Hassan - Independent Prescriber
Last Updated: 2025-01-14